Table 3.
Clinical response | Cycle 3 N = 45 |
Cycle 7 N = 41 |
Cycle 12 N = 40∗ |
Best response N = 45 |
---|---|---|---|---|
Overall response, % | 78 | 100 | 98† | 100 |
CR(u)/CRi‡, % | 2 | 15‡ | 38 | 42 |
PR, % | 76 | 85 | 60 | 58 |
MRD response | Cycle 12∗ |
Cycle 18 |
Cycle 24 |
|
---|---|---|---|---|
Peripheral Blood N = 42 |
Bone marrow N = 39 |
Peripheral Blood |
||
N = 29 | N = 25 | |||
Detectable >10−2, % | 2 | 2 | ||
Detectable 10−4 to 10−2, % | 31 | 21 | 10 | 4 |
Undetectable <10−4, % | 67 | 77 | 90 | 96 |
CR, complete repsonse; CRu, unconfirmed CR because of absence of confirmatory bone marrow biopsy; CRi, CR with incomplete hematologic recovery; PR, partial response.
Forty patients had clinical response available at cycle 12 and 42 had MRD assessments at cycle 12.
One patient had PR at cycle 7 and progressive disease at cycle 12.
Cycle 3 and cycle 7 CRs are CRu.