Figure 8.

MRI and PAI performance of CaF₂:Y,Gd,Nd NPs. (a) The VSM measurement of CaF₂:Y,Gd,Nd NPs; (b) MRI signal intensity of different concentrations of CaF₂:Y,Gd,Nd NPs with longitudinal magnetization recovery and transverse magnetization decay; (c) in vitro T₁ and T₂ relaxation rates of different Gd concentrations; inset shows T₁-weighted and T₂-weighted MR images of CaF₂:Y,Gd,Nd NPs at different concentrations in 1% agarose gel; (d) ex vivo MRI images before and after subcutaneous injection of CaF₂:Y,Gd,Nd NPs (10 mg/mL) into a mouse cadaver; (e) in vitro PA images (2D and 3D) of CaF₂:Y,Gd,Nd NPs (10 mg/mL), water is the control; and (f) ex vivo PA images (3D) before and after injection of CaF₂:Y,Gd,Nd NPs (10 mg/mL) into a mouse. Unspecific signal is caused by endogenous tissue chromophores.