Table 1.
Assays to predict MIE and KEs for cardiotoxicity.
| ASSAYS to Increase of Oxidative Stress | ASSAYS to Increase in Mitochondrial Dysfunction | ASSAYS to Inhibition of Mitochondrial Complexes |
|---|---|---|
| APR HepG2 P-H2AX 24 h dn | APR HepG2 MitoMass 24 h dn | CCTE Simmons MITO basal resp rate OCR dn |
| APR HepG2 P-H2AX 24 h up | APR HepG2 MitoMass 24 h up | CCTE Simmons MITO basal resp rate OCR up |
| APR HepG2 P-H2AX 72 h dn | APR HepG2 MitoMass 72 h dn | CCTE Simmons MITO inhib resp rate OCR dn |
| APR HepG2 P-H2AX 72 h up | APR HepG2 MitoMass 72 h up | CCTE Simmons MITO inhib resp rate OCR up |
| APR HepG2 StressKinase 24 h dn | APR HepG2 MitoMembPot 24 h dn | CCTE Simmons MITO max resp rate OCR dn |
| APR HepG2 StressKinase 24 h up | APR HepG2 MitoMembPot 24 h up | CCTE Simmons MITO max resp rate OCR up |
| APR HepG2 StressKinase 72 h dn | APR HepG2 MitoMembPot 72 h dn | |
| APR HepG2 MitoMembPot 72 h up | ||
| ATG XTT Cytotoxicity up | ||
| TOX21 MMP ratio down | ||
| TOX21 MMP ratio up | ||
| TOX21 MMP rhodamine |