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Pharmacokinetic properties of compound 48.
| Cpd No. | Administration | Cmax (ng/mL) | t½ (h) | CL (mL/h/kg) | AUC 0–t
(nL/L·h) |
F |
|---|---|---|---|---|---|---|
| 48 | i.v. (2 mg/kg) | 587 ± 63.1 | 1.33 ± 0.11 | 82.7 ± 1.97 | 400 ± 9.29 | n.a. |
| p.o. (10 mg/kg) | 252 ± 22.0 | 1.20 ± 0.12 | — | 654 ± 125 | 31.8% |
