Table 3.

Ketamine interaction with certain drugs.

Drugs/Drug Groups	Side Effects/Interactions
Alcohol	Central nervous system depression (respiratory depression, sedation, coma)
Amphetamine/Dextroamphetamine/Lisdexamfetamine	Cardiac effects (arrythmia)
Benzodiazepines (clonazepam, lorazepam)	Central nervous system depression (respiratory depression, sedation, coma)
CYP3A4 inhibitors (ketoconazole, clarithromycin, grapefruit juice)	Increased plasma drug concentrations of ketamine
Doxazosin	Hypotension
Doxepin	Central nervous system depression (respiratory depression, sedation, coma)
Hydroxyzine	Central nervous system depression (respiratory depression, sedation, coma)
Haloperidol	Additive central nervous system effects(dizziness, drowsiness, impairment in thinking)
Mirtazapine	Additive central nervous system effects(dizziness, impairment in thinking, judgment)
Nortriptyline	Central nervous system depression (respiratory depression, sedation, coma)
Neuromuscular blockers (tubocurarine, atracurium)	Neuromuscular blockade
Propranolol	Hypotension
Pregabalin	Central nervous system depression (respiratory depression, sedation, coma)
Trazodone	Central nervous system depression (respiratory depression, sedation, coma)
Theophylline	Increased risk of seizures