Table 3.
Univariate analysis for factors affecting eradication rates of 14-day hybrid therapy in the first line treatment of H. pylori infection among the modified intention-to-treat population.
| Characteristics | Patient Number | Eradication Rate | p Value |
|---|---|---|---|
| Sex | 0.351 | ||
| Male | 266 | 255 (95.9%) | |
| Female | 308 | 290 (94.2%) | |
| Age | 0.175 | ||
| <60 years old | 327 | 314 (96.0%) | |
| ≧60 years old | 247 | 231 (93.5%) | |
| Cigarette smoking | 0.939 | ||
| Yes | 102 | 97 (95.1%) | |
| No | 472 | 448 (94.9%) | |
| Alcohol drinking | 0.715 | ||
| Yes | 43 | 42 (97.75%) | |
| No | 531 | 503 (94.7%) | |
| Coffee consumption | 0.762 | ||
| Yes | 132 | 126 (95.4%) | |
| No | 442 | 419 (94.8%) | |
| Tea consumption | 0.204 | ||
| Yes | 180 | 174 (96.7%) | |
| No | 394 | 371 (94.2%) | |
| Peptic ulcer | 0.108 | ||
| Yes | 216 | 201 (93.1%) | |
| No | 358 | 344 (96.1%) | |
| Antibiotic resistance | |||
| Clarithoromycin | <0.001 * | ||
| Susceptible | 287 | 280 (97.6%) | |
| Resistant | 54 | 45 (83.3%) | |
| Amoxicillin | 1.000 | ||
| Susceptible | 340 | 325 (95.6%) | |
| Resistant | 1 | 1 (100%) | |
| Metronidazole resistance | 0.935 | ||
| Susceptible | 208 | 199 (95.7%) | |
| Resistant | 133 | 127 (95.5%) | |
| Tetracycline | — | ||
| Susceptible | 341 | 326 (95.6%) | |
| Resistant | 0 | — | |
| Type and dose of PPI | 0.064 | ||
| Esomeprazole 40 mg bid | 115 | 114 (99.1%) | |
| Pantoprazole 40 mg bid | 162 | 151 (93.2%) | |
| Rabeprazole 20 mg bid | 297 | 280 (94.3%) | |
| Drug adherence | 0.005 * | ||
| Good | 559 | 534 (95.5%) | |
| Poor | 15 | 11 (73.3%) |
* denotes significant difference. (MIC breakpoint of clarithromycin: 1 μg/mL).