FIG. 1.

Lp(a) inhibits LPS-induced TNF production by human PBMC. (a) LPS in various concentrations was preincubated with Lp(a) or LDL for 24 h before being added to the cells. Lp(a) and LDL determined a significant inhibition of LPS-induced TNF production (data are given as percentage of control production in the presence of LPDP. (b) A dose response curve for the neutralization effect was obtained when LPS (1 ng/ml) was preincubated with various dilutions of Lp(a) and LDL in LPDP. The data represent means plus or minus the standard deviations of four experiments with similar results (n = 8).