Table 5.

Studies on other NPs applied for nano-DDS formation in OC therapy.

Nanocarrier	Active Agent	Assembly Method	Mechanism	Advantages	Ref.
RNA Micelles	Anti-miRNA	The phi29 packaging RNA three-way junction(pRNA-3WJ) was used as a scaffold to construct micelles. An oligo with 8 nt locked nucleic acid (LNA) complementary to the seed region of microRNA21(miR21) was included in the micelles as an interference molecule for cancer inhibition	Internalization of anti-miRNA inhibited the function of oncogenic miR21, enhanced the expression of the pro-apoptotic factor, and induced cell apoptosis	The RNA micelles carrying anti-miR21 showed strong binding and internalization to cancer cells, inhibited the function of oncogenic miR21, enhanced the expression of the pro-apoptotic factors, and induced cell apoptosis. Animal experiments revealed effective tumor targeting and inhibition of RNA micelles in xenograft models.	[57]
Nano-niosomes	Cur	Niosomes containing Cur were prepared by the thin-film hydration method	Cur counteracted the effects of 4-NQO to cause cancer in the oral tissue through its antioxidant properties	The use of injectable Cur niosomes significantly prevented the development of severe forms of dysplasia. According to the results obtained from the culture medium of KB OC cells, Cur-loaded niosomes were found to be significantly effective in inhibiting the growth and necrosis of cancer cells compared with free Cur.	[194]