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. 2024 Jan 12;151(2):dev202446. doi: 10.1242/dev.202446

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© 2024. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — ACKR3 is dispensable for RGC axon guidance at the optic chiasm. (A) In situ hybridisation of coronal sections from E12.5, E14.5 and E17.5 wild-type mouse eyes with a probe specific for Ackr3. Arrows indicate expression in the RGC layer, arrowheads indicate expression in radially oriented cells. D, dorsal; V, ventral. (B) Ventral views of the optic pathway anterogradely labelled with DiI in E14.5 Ackr3 wild-type and mutant embryos. Boxed region is shown at higher magnification in the lower panels, brackets indicate the width of the ipsilateral projection. Number analysed of each genotype was: Ackr3^+/+ n=3, Ackr3^−/+ n=3, Ackr3^−/− n=4. Graph displays quantification of the Ipsilateral Index with each dot representing the value for one embryo and horizontal bars the mean values. Scale bars: 200 µm.