Platelet count, platelet size, and percentage of reticulated platelet in control mice and tumor-bearing mice. Platelet count and size were measured using an Element HT5 analyzer. (A) Platelet count in control mice (n = 21) and tumor-bearing mice (n = 15). (B) Platelet size in control mice (n = 15) and tumor-bearing mice (n = 15). (C) Percentage of reticulated platelets in control mice (n = 15) and tumor-bearing mice (n = 9). All data are shown as mean ± SD and analyzed by the two-tailed Student’s t-test. ***p < 0.001, ****p < 0.0001. MPV, mean platelet volume; SD, standard deviation.