Table 2.
IC50 values (µM) ± SD determined vs. protein or polyphenol (PE) concentrations of AFPE and Peaks 1–4 for the inhibition of enzymes, as well as Aβ 1–40 fibril formation and reversion.
| AFPE | Peak 1 | Peak 2 | Peak 3 | Peak 4 | |
|---|---|---|---|---|---|
| Enzyme | PE (µM) | Protein (µM) | PE (µM) | PE (µM) | PE (µM) |
| AChE | 859 ± 18 # | 5.53 ± 0.09 | 23.43 ± 0.99 | 32.30 ± 0.17 | 43.67 ± 2.33 |
| BuChE | 966 ± 72 # | N.D. | 73.14 ± 1.29 | 101.35 ± 3.60 | 12.70 ± 0.60 |
| MAO-A | 145 ± 30 # | 1.71 ± 0.05 | 84.61 ± 5.64 | 79.60 ± 0.50 | 62.92 ± 2.48 |
| MAO-B | 199 ± 70 # | 16.43 ± 1.06 | 15.77 ± 0.12 | 19.63 ± 0.34 | 6.33 ± 0.02 |
| Fibrillation process | |||||
| Inhibition of Aβ 1–40 fibril formation | 1396.00 ± 3.05 | 9.16 ± 0.52 | 44.47 ± 1.54 | N.D. | 37.11 ± 0.41 |
| Reversion of Aβ 1–40 fibrils | 616.70 ± 2.65 | N.D. | N.D. | N.D. | 104.87 ± 43.02 |
Values are expressed as the mean ± SD calculated from at least three different determinations; # reference [32].