Table 4.
Representatively engineered MBGs-based nanoplatforms and systems for cancer diagnosis and therapy.
| Nanoplatforms | Engineering strategies | Therapeutic advantages | Ref. |
|---|---|---|---|
| Multifunctional Eu-Gd-Si-Ca MBGs | Integration of Eu-Gd-Si-Ca active irons into MBGs for tumor imaging, inhibiting recurrence and promoting impaired tissue regeneration. | Controlled biodegradation; Ultrahigh drug loading; PH responsive release; Tumor cell-targeted surface; Branched mesoporous structure; Special magneto-optical properties. |
[254] |
| Aminated MBGs | Aminated MBGs were applied for alendronate delivery. | Large surface area; Controlled drug delivery; Stimulatory bone regeneration. |
[225] |
| MBGs/polyurethane nanocomposites | Bioactive nanocomposite was fabricated by using MBGs and biodegradable polyurethane. | Controlled delivery; Enhanced mechanical property. |
[41] |
| Dendritic MBGs nanosphere | Dendritic MBGs were fabricated by adjusting calcium content in silica matrix system. | Large specific surface area; Variable mesoporous channels; Controlled anti-cancer drug delivery; Calcium influx-mediated specific tumor suppression. |
[46] |
| Europium-containing MBGs | Doping of Eu ions into MBGs for intelligent delivery of doxorubicin. | Large surface area; High pore volume; Enhanced mechanical property; Controlled drug delivery; Stimulatory bone regeneration. |
[149] |
| Sm/MBGs/Alginate microspheres | Incorporation of Sm into the network of MBGs; Surface functionalization of MBGs with alginate hydrogels. |
Acceptable biocompatibility; Controlled drug delivery; Stimulatory bone regeneration; Microenvironment modulation. |
[78] |
| Multifunctional magnetic MBGs | Incorporating Fe/Fe3O4 into the nanostructure of MBGs for tumor therapy. | Super-paramagnetic features; Improved mechanical property; Controlled drug delivery; Hyperthermia and photothermal properties. |
[[255], [256], [257]] |
| Copper-containing magnetic MBGs | Impregnation of copper ion into the nanostructure of magnetic MBGs for infectious diseases and tumor therapy. | Acceptable bioactivity; Antibacterial activity; Super-paramagnetism features; Controlled drug delivery; Stimulatory bone regeneration. |
[216] |
| Molecular gated MBGs | Surface functionalization of MBGs with adenosine triphosphate (ATP) and e-poly-llysine molecular gates. | Superior biodegradability; High surface area; Dual-drug loading system; Controlled drug delivery. |
[45] |