Table 3.

Sensitivity analyses of the reverse MR study

Exposure	Outcome	SNP (n)	Heterogeneity tests	Cochran’s Q	P value	Horizontal pleiotropy tests	Intercept	P value
Migraine	AR	12	IVW	8.118	0.703	MR Egger intercept test	0.001	0.426
			MR Egger	7.430	0.684	MR-PRESSO global test	NA	0.850
MA	AR	8	IVW	10.557	0.159	MR Egger intercept test	0.000	0.874
			MR Egger	10.509	0.105	MR-PRESSO global test	NA	0.693
MO	AR	10	IVW	8.774	0.458	MR Egger intercept test	0.002	0.126
			MR Egger	5.858	0.663	MR-PRESSO global test	NA	0.129

AR, allergic rhinitis; MA, migraine with aura; MO, migraine without aura; SNP, single nucleotide polymorphism; IVW, inverse variance weighted; MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier; NA, not available