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. 2024 Jan 11;341:199308. doi: 10.1016/j.virusres.2024.199308

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© 2024 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — Relationship among HCVpps based on neutralization sensitivity. (A) Principal component analysis (PCA) of HCVpps based on neutralization IC₅₀ values. First two principal components (PC1 and PC2) are plotted and percentage of variation captured by each PC is indicated in brackets. HCVpps from cluster 1 and 2 are colored in gray and orange, respectively. HCVpps selected for the final panel are in bigger circles compared to the non-selected HCVpps. (B) Loading bar plots from the PCA loadings of the mAbs for PC1 and PC2. (C) Serum pool ID₅₀ values against the selected HCVpps. HCVpps are arranged from most sensitive to most resistant based on the mAb sensitivity (Fig. 1). (D) Correlation between the serum pool ID₅₀ values and mAbs geometric titer (GMT) against the different HCVpps are shown.