TABLE 5.

Degradation of cytokines by bacterial proteases

Organism	Cytokine(s) degraded	Enzyme(s) responsible	Reference(s)
Pseudomonas aeruginosa	IL-2, TNF-α	Alkaline protease, elastase	42, 50
	IFN-γ	Alkaline protease	30
Legionella pneumophila	IL-2	Zn-metalloproteinase	41
Porphyromonas gingivalis	IL-1β, IL-6, IL-1ra	Gingipain	16, 17