Figure 2.
Bacteriome composition with the PCA showing the vectors for phyla. Samples from CD patients off therapy were driven mostly by the phylum Bacteroidota, including genera with colitis-inducing potential,67 which are found more often in CD patients thanin healthy individuals,40 and by the phylum Proteobacteria, driven mostly by genera associated with dysbiosis in CD patients.37 The samples of CD on therapy were closer to the clusters of JIA patients, and healthy controls, driven mostly by the phylum Firmictues with genera known to be associated with better gut health.37,40 The change in the bacteriome composition can be explained by both the gut health status and the bacteriome’s alpha-diversity. Put simply, the more Bacteroidota [more negative on axis 1], the lower the alpha diversity, and similarly, the more Proteobacteria [the more negative on axis 2], the lower the diversity and the worse gut health.