Table 3.

Faecal metabolites whose quantity changed significantly with anti-TNF therapy in CD.

	The change with anti-TNF therapy in patients with CD		Statistics for these metabolites in patients with JIAb
	Metabolite abundance change on therapya	p-value: raw [corrected for the number of tested metabolites]	Metabolite abundance change on therapya	Raw p-value
Isoleucine	Decrease	1.6 × 10−4 [0.004]	Increase	0.84, NS
Uracil	Decrease	9.6 × 10−4 [0.002]	Increase	0.94, NS
Glucose	Increase	0.002 [0.03]	Decrease	0.38, NS
Glycerol	Increase	6.17 × 10−5 [0.003]	Decrease	0.94, NS

^aCoefficients are not reported as they reflect the absolute change in units of the area under the peak, which is meaningless to interpret.

^bIn JIA, none of 57 tested metabolites showed a significant change with anti-TNF: the lowest raw p-value was 0.027, corresponding to a corrected p of 0.74.

NS, not significant.