TABLE 4.
Nailfold videocapillaroscopy findings in CSU patients with aiCSU characteristics compared to CSU patients without.
| NVC quantitative assessment | Presence/History of AID (n = 11) | High Anti‐TPO (n = 9) | Low IgE (n = 12) | Low IgE and/or high anti‐TPO (n = 19) | Presence of ANA (n = 12) | Positive ASST (n = 26) |
|---|---|---|---|---|---|---|
| Mean capillary density/linear mm, (SD) | 7.58 (0.99) | 7.63 (0.32) | 7.85 (0.27) | 7.75 (0.21) | 7.55 (0.27) | 7.35 (0.83) |
| p‐value | 0.87 | 0.24 | 0.06 | 0.01 | 0.83 | 0.72 |
| Mean total nb of normal cap/linear mm, (SD) | 6.89 (1.11) | ND | ND | 7.03 (0.23) | ND | 6.79 (0.95) |
| p‐value | 0.97 | 0.14 | 0.91 | |||
| Mean total nb of abnormal cap/linear mm, (SD) | 0.70 (0.51) | 0.72 (0.20) | 0.65 (0.08) | 0.72 (0.1) | 0.62 (0.12) | 0.55 (0.36) |
| p‐value | 0.66 | 0.25 | 0.81 | 0.11 | 0.84 | 0.33 |
| %Abnormal/total nb cap, (SD) | 9.24 (0.26) | ND | ND | 9.40 (1.42) | ND | 7.67 (5.5) |
| p‐value | 0.63 | 0.09 | 0.51 | |||
| Mean total nb of ramified cap/linear mm, (SD) | 0.26 (0.20) | 0.22 (0.07) | 0.17 (0.05) | 0.21 (0.04) | 0.20 (0.06) | 0.15 (0.17) |
| p‐value | 0.047 | 0.28 | 0.1 | 0.69 | 0.42 | 0.63 |
| %Ramified/total nb cap, (SD) | 42.45 (23.84) | ND | ND | 29.58 (5.39) | ND | 27.36 (22.35) |
| p‐value | 0.005 | 0.98 | 0.55 | |||
| Mean total nb of concave cap/linear mm, (SD) | 0.18 (0.15) | 0.16 (0.05) | 0.18 (0.03) | 0.18 (0.03) | 0.18 (0.03) | 0.14 (0.12) |
| p‐value | 0.41 | 0.74 | 0.27 | 0.78 | 0.36 | 0.72 |
| %Concave/total nb cap, (SD) | 23.40 (13.36) | ND | ND | 31.44 (5.78) | ND | 33.80 (28.77) |
| p‐value | 0.39 | 0.54 | 0.59 | |||
| Mean total nb of crossing cap/linear mm, (SD) | 0.25 (0.24) | 0.34 (0.11) | 0.30 (0.07) | 0.32 (0.06) | 0.23 (0.07) | 0.26 (0.27) |
| p‐value | 0.33 | 0.4 | 0.87 | 0.07 | 0.2 | 0.36 |
| %Crossing/total nb cap, (SD) | 34.14 (20.05) | ND | ND | 39.91 (6.51) | ND | 40.57 (32) |
| p‐value | 0.18 | 0.44 | 0.91 | |||
| Mean total nb of reg. enlarged cap/linear mm, (SD) | 0.23 (0.23) | 0.19 (0.03) | 0.34 (0.13) | 0.27 (0.08) | ND | 0.57 (0.52) |
| p‐value | 0.049 | 0.15 | 0.28 | 0.01 | 0.71 | |
| Mean total nb of irreg. enlarged cap/linear mm, (SD) | 0.04 (0.06) | 0.05 (0.03) | 0.04 (0.02) | 0.05 (0.02) | ND | 0.10 (0.20) |
| p‐value | 0.31 | 0.89 | 0.28 | 0.006 | 0.71 | |
| Mean total nb of giant cap/linear mm, (SD) | 0 (0) | ND | ND | ND | ND | 0 (0) |
| p‐value | 0.69 | 0.19 | ||||
| Mean total nb of dilated cap/linear mm, (SD) | 0.27 (0.24) | 0.24 (0.05) | 0.37 (0.14) | 0.32 (0.09) | 0.39 (0.17) | 0.70 (0.66) |
| p‐value | 0.048 | 0.2 | 0.22 | 0.003 | 0.24 | 0.68 |
| %nb dil/tot nb cap, (SD) | 3.68 (3.40) | ND | ND | 3.9 (1.05) | ND | 9.36 (9.40) |
| p‐value | 0.07 | <0.001 | 0.73 | |||
| Mean total nb of microhemorrhages/linear mm, (SD) | 0.01 (0.03) | 0 (0) | 0.03 (0.02) | 0.02 (0.01) | 0.05 (0.03) | 0.04 (0.09) |
| p‐value | 0.22 | 0.24 | 0.92 | 0.14 | 0.32 | 0.79 |
| Mean NVC plexus score, (SD) | 0.41 (0.36) | 0.31 (0.10) | 0.28 (0.10) | 0.28 (0.07) | 0.35 (0.10) | 0.34 (0.53) |
| p‐value | 0.67 | 0.76 | 0.51 | 0.49 | 0.99 | 0.49 |
Note: P‐values are considered statistically significant when p < 0.05 (bold).
Abbreviations: AID, auto‐immune diseases; ANA, antinuclear antibodies; ASST, autologeous serum skin test; CSU, chronic spontaneous urticaria; ELISA, enzyme linked immunosorbent assay; F, female; HC, Healthy Controls; IgE, Immunoglobulin E; irreg., irregularly; M, male; Nb, number; NVC, nailfold videocapillaroscopy; PCR, polymerase chain reaction; reg., regularly; SCF, stem cell factor; SD, standard deviation; TPO, thyroid peroxidase; VEGF, vascular endothelial growth factor.