. 2024 Jan 26;16:92287. doi: 10.52965/001c.92287

Table 2. Common side effects of antibiotics used in TJA.

Oral antibiotics	Common side effects
Penicillin	Skin rash, anaphylaxis, C. difficile-associated diarrhea^83,86,89
Amoxicillin	Skin rash, anaphylaxis, C. difficile-associated diarrhea^83,86,89
Amoxicillin-clavulanate	Skin rash, anaphylaxis, C. difficile-associated diarrhea^83,86,89
Cefadroxil	Skin rash, anaphylaxis, C. difficile-associated diarrhea^83,86,89
Cephalexin	Skin rash, anaphylaxis, C. difficile-associated diarrhea^83,86,89
Ciprofloxacin	Hepatotoxicity, Achilles tendinitis/ruptures, neuropathy, C. difficile-associated diarrhea^83,86,89
Levofloxacin	Hepatotoxicity, Achilles tendinitis/ruptures, neuropathy, C. difficile-associated diarrhea^83,86,89
Clindamycin	C. difficile-associated diarrhea^83,86,89
Doxycycline	Skin hyperpigmentation, hepatotoxicity^83,86,89
Minocycline	Skin hyperpigmentation, hepatotoxicity^83,86,89
Rifampin	Hepatotoxicity, skin rash, gastrointestinal upset, drug interactions, interstitial nephritis, cytopenia^83,86,89
Cotrimoxazole	Leucopenia/anemia, skin rash^83,86,89
Linezolid	Thrombocytopenia/anemia, serotonin syndrome w/TCAs, myelosuppression, optic neuritis, peripheral neuropathy^83,86,89

NOTE. – TJA = Total Joint Arthroplasty; TCAs = Tricyclic antidepressants.