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. 2024 Jan 27;15:828. doi: 10.1038/s41467-023-44348-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Kaplan–Meier survival curve of leukemia-bearing mice fed SD or CR and treated or not with LSD1i: AML-IEO20 PDX with the MLL-AF9 translocation (SD, n = 4; CR, n = 5; SD+LSD1i, n = 4; CR+LSD1i, n = 5) (p = 0.02; CR +LSD1i vs. CR). “n” represents the number mice per group. Statistical analysis was performed using log-rank (Mantel–Cox) test. b DEPMAP analysis of CFLAR dependency vs LSD1 (KDM1A). Linear regression parameters are overlayed. Impact of CR and LSD1 inhibition on tumor growth of PDX-BC1 (c) and PDX-BC2 (d) over time. Inserts show tumor growth at the end of the observation period (102 days for PDX-BC1 and 54 days for PDX-BC2 for CR and CR+LSD1i group as indicated. For PDX-BC1 (SD, n = 5; CR, n = 3; SD+LSD1i, n = 6; CR+LSD1i, n = 4) and for PDX-BC2, (SD, n = 8; CR, n = 6; SD+LSD1i, n = 8; CR+LSD1i, n = 6) where “n” is the number mice per group. Mice with non-palpable tumor during the entire experiment were removed from the analysis. Data are shown as mean ± SD. Statistical analysis was performed using two tailed t-test between CR and CR+LSD1i group. Source data are provided as a Source Data file.