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. 2024 Jan 27;15:821. doi: 10.1038/s41467-024-45199-x

Fig. 1. Single-cell multiome assays dissect transcriptome and epigenome changes of the developing mouse secondary palate.

Fig. 1

a Schematic plot depicts the development of mouse secondary palate (pink) spanning embryonic day (E) 12.5 (n = 2), E13.5 (n = 3), E14.0 (n = 2), and E14.5 (n = 2). The isolated nuclei were subjected to 10x Chromium Multiome sequencing to profile scRNA-seq and scATAC-seq simultaneously within the same cells. b, c Uniform manifold approximation and projection (UMAP) visualization of 36,154 cells based on RNA assay (b) or ATAC assay (c). Each dot represents one cell and is colored by the developmental stage (left) and annotated cell types (right). d, e Dot plot illustrates marker gene expression (x axis) (d) and gene activity (e) (x axis) across cell types (y axis). Dot size is proportional to the percent of expressed cells. Colors indicate low (purple) to high (yellow) expression.