Table 1.
Top five putative regulators in each major cell type
| Cell type | Gene symbol | RNA. P value | Motif | Motif. P value |
|---|---|---|---|---|
| CNC-derived mesenchymal | Twist2 | 3.00E-241 | MA0633.1 | 0.00E + 00 |
| Lhx8 | 0.00E + 00 | MA0705.1 | 2.01E-61 | |
| Foxf1 | 2.97E-192 | MA1606.1 | 5.41E-133 | |
| Shox2 | 6.76E-211 | MA0720.1 | 1.72E-73 | |
| Tcf3 | 2.01E-05 | MA0092.1 | 2.03E-257 | |
| Epithelial | Sox2 | 0.00E + 00 | MA0142.1 | 2.94E-88 |
| Sox6 | 2.16E-225 | MA0515.1 | 2.05E-197 | |
| Smad3 | 1.38E-144 | MA1622.1 | 8.26E-215 | |
| Klf12 | 1.00E-09 | MA0742.1 | 0.00E + 00 | |
| Runx1 | 2.58E-233 | MA0002.2 | 1.30E-36 | |
| Endothelial | Foxo1 | 8.90E-145 | MA0480.1 | 4.91E-18 |
| Nr2f6 | 7.22E-07 | MA0677.1 | 3.08E-113 | |
| Sox17 | 0.00E + 00 | MA0078.1 | 9.56E-30 | |
| Nr5a2 | 7.58E-145 | MA0505.1 | 5.63E-37 | |
| Esrrg | 1.69E-15 | MA0643.1 | 1.39E-57 | |
| Myeloid | Runx1 | 6.16E-104 | MA0002.2 | 1.24E-08 |
| Nfe2l2 | 1.67E-65 | MA0150.2 | 5.29E-29 | |
| Arnt | 4.93E-04 | MA0004.1 | 9.49E-21 | |
| Bach1 | 7.34E-03 | MA0591.1 | 3.27E-23 | |
| Nr4a2 | 1.72E-03 | MA0160.1 | 5.49E-22 | |
| Myogenic precursors | Tcf12 | 2.09E-06 | MA0521.1 | 1.73E-115 |
| Tcf21 | 3.08E-68 | MA0832.1 | 5.97E-105 | |
| Plagl1 | 2.07E-16 | MA1615.1 | 1.68E-03 | |
| Arx | 3.20E-63 | MA0874.1 | 7.88E-06 | |
| Nobox | 3.39E-04 | MA0125.1 | 4.40E-06 | |
| Glial | Sox5 | 8.83E-146 | MA0087.1 | 1.65E-04 |
| Nr4a2 | 5.35E-48 | MA0160.1 | 2.39E-42 | |
| Creb5 | 1.91E-63 | MA0840.1 | 3.30E-22 | |
| Dlx1 | 1.64E-138 | MA0879.1 | 1.23E-04 | |
| Rxra | 3.50E-04 | MA0065.2 | 3.97E-52 | |
| Neuronal | Arid3b | 1.37E-06 | MA0601.1 | 3.29E-05 |
| Hmx2 | 5.68E-177 | MA0897.1 | 8.05E-03 | |
| Zic1 | 1.03E-06 | MA1628.1 | 8.97E-03 |
The Wilcoxon rank-sum test is utilized, and the Benjamini–Hochberg method is applied for multiple test adjustment of the P value.