Table 2.
Marker genes in anterior and posterior subpopulations
| Subpopulation | Gene symbol | Average log2(fold change) | Adjusted P value | Cleft-related gene |
|---|---|---|---|---|
| Anterior palatal mesenchymal subpopulation | Shox2 | 2.48 | 2.84E-124 | Yes |
| Satb2 | 1.74 | 2.49E-105 | No | |
| Zfhx4 | 1.66 | 4.80E-79 | No | |
| Adgrl2 | 1.22 | 3.45E-73 | No | |
| Alx1 | 1.21 | 1.20E-62 | Yes | |
| 2700069I18Rik | 1.05 | 5.86E-56 | No | |
| Eya1 | 1.24 | 2.00E-54 | Yes | |
| Thsd4 | 1.27 | 6.39E-54 | No | |
| Mme | 1.23 | 6.44E-50 | No | |
| Slit2 | 1.60 | 2.81E-47 | No | |
| Sox5 | 1.28 | 7.45E-46 | Yes | |
| Ror1 | 0.91 | 6.19E-40 | No | |
| Asb4 | 1.13 | 6.69E-39 | No | |
| Six1 | 0.86 | 9.30E-39 | Yes | |
| Msx1 | 0.66 | 1.71E-34 | Yes | |
| Posterior palatal mesenchymal subpopulation | Meox2 | 1.67 | 1.10E-110 | Yes |
| Dach1 | 2.17 | 4.02E-107 | No | |
| Pcdh9 | 2.45 | 2.59E-97 | No | |
| Col25a1 | 2.20 | 6.60E-95 | No | |
| Inpp4b | 2.60 | 6.64E-90 | No | |
| Prickle1 | 1.47 | 1.77E-85 | Yes | |
| Sim2 | 1.23 | 3.38E-78 | Yes | |
| Lmo4 | 1.73 | 4.50E-75 | No | |
| Pcdh15 | 3.10 | 1.09E-73 | No | |
| Cdh18 | 1.97 | 6.17E-68 | No | |
| Hs3st5 | 1.49 | 2.58E-64 | No | |
| Efnb2 | 1.15 | 7.93E-64 | Yes | |
| Tmtc2 | 1.58 | 1.15E-61 | No | |
| Fhod3 | 1.45 | 7.66E-61 | No | |
| Pam | 1.22 | 3.93E-50 | No |
The Wilcoxon rank-sum test is utilized, and the Benjamini–Hochberg method is applied for multiple test adjustment of the P value.