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. 2024 Jan 27;14:2292. doi: 10.1038/s41598-024-52565-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Bulk RNA sequencing of sorted podocytes under healthy conditions (Pod^TOM untreated) and on day 5 after NTN induction (Pod^TOM NTN Day 5) reveals profound transcriptional changes in cytoskeletal, adhesion and proinflammatory pathways during GN. (A) Principal component analysis of podocytes from healthy and nephritic mice reveals robust clustering into healthy (n = 3) and injured conditions (n = 3). (B) MA-Plot of differentially and significantly expressed genes (adj. p-value < 0.05) reveals 2915 up- and 2328 downregulated genes in Pod^TOM NTN Day 5 vs. Pod^TOM untreated podocytes. If multiple transcripts were present, only the one with CCDS entry, high transcript support level and highest effect size (in that order) was considered. (C) Heatmap of the top 50 regulated genes with adj. p-value < 0.05. (D) Chord plot of the top 10 significantly enriched biological pathways (q-value < 0.1) linked among the 100 top-regulated genes ordered by their beta-value (effect size).