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. 2024 Jan 27;14:2292. doi: 10.1038/s41598-024-52565-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Bulk RNA sequencing of nephritic MyD88^pko podocytes reveals MyD88 independent signaling pathways in GN. (A) Principal component analysis of podocytes isolated from nephritic mice at day 5 after NTS injection with intact MyD88 signaling (Pod^TOM) (n = 3) and nephritic mice with podocyte specific Myd88 knock out (MyD88^pko) (n = 3). (B) MA-Plot of differentially and significantly expressed genes (adj. p-value < 0.05) genes reveals 125 up- and 111 downregulated genes. If multiple isoforms were present, only the one with CCDS entry, high transcript support level and highest effect size (in that order) was considered. (C) Heat map of the top 50 regulated and significant genes (adj. p-value < 0.05). (D) Chord plot of top 10 significantly enriched pathways (q-value < 0.1) linked among the 100 top-regulated genes ordered by their beta-value (effect size). (E) Expression profiles of podocyte markers, cytokine receptors, chemokines/cytokines and members of the TLR signaling pathways for the indicated comparisons between groups (p-value < 0.05).