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. 2024 Jan 27;15:830. doi: 10.1038/s41467-024-45044-1

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© The Author(s) 2024, corrected publication 2024

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Fig. 8 — Age-associated mitochondrial malfunction leads to mtDNA release triggering cGAS/STING activation and type I IFN response in mice and humans. Restoring mitochondrial homeostasis using UA constrained mtDNA leakage, reduced inflammation and improved healthspan. Created with BioRender.com.