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. 2024 Jan 27;108(1):179. doi: 10.1007/s00253-023-12927-0

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© The Author(s) 2024

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Fig. 6 — Cellular immune response in mice vaccinated with AZD1222 (AZ) and boosted with AZ or rRBD-delta. A Plots showing the gating strategy to analyze CD4 and CD8 T cells in nonstimulated and CD3-stimulated controls. The cells were stained with zombie NIR and fluorescent CD4, CD8, and IFNγ antibodies. A region was selected for single living cells. IFNγ+CTV low cells were selected for analysis. Splenocytes from immunized mice (n = 5 per group) were stained with CTV and stimulated with B RBD-delta or C a peptide mixture for 3 days. D Summary of proliferation analysis showing percentages of CD4+/IFNγ+ and CD8+/IFNγ+ antigen-specific cells from individual mice immunized once, twice, or three times with AZD1222 and boosted or not with RBD. Asterisks indicate statistically significant differences between immunized mice with or without boost (P < 0.05)