Table 3.
Associations between definite antimicrobial therapy and the different outcomes (reference definite therapy with carbapenems)
| Univariable | Multivariablea | Univariable robust | Multivariable robusta | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | OR | 95% CI | p-value | OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Primary outcomes | ||||||||||||
| In-hospital death | .46 | .18; 1.18 | 0.107 | .77 | .28; 2.18 | 0.628 | .46 | .19 1.16 | 0.101 | .77 | .27; 2.19 | 0.630 |
| New renal impairment | .54 | .21; 1.39 | 0.199 | .54 | .20; 1.47 | 0.230 | .54 | .21; 1.41 | 0.208 | .54 | .20; 1.48 | 0.233 |
| Neurological adverse events | .21 | .07; .61 | 0.004 | .26 | .09; .79 | 0.018 | .21 | .07; .61 | 0.004 | .26 | .09; .80 | 0.018 |
| Secondary outcomes | ||||||||||||
| Length of stay (survivors) b | -27.50 | -44.87; -4.61 | 0.022 | -27.48 | -45.97; -2.66 | 0.032 | -27.50 | -45.59; -3.35 | 0.028 | -27.48 | -46.63; -1.46 | 0.040 |
| First recurrent infection | 0.51 | 0.18; 1.42 | 0.195 | 0.69 | 0.23; 2.05 | 0.501 | 0.51 | 0.18; 1.45 | 0.206 | 0.69 | 0.21; 2.21 | 0.528 |
| Second recurrent infection c | 3.56 | 0.40; 31.23 | 0.253 | 6.64 | 0.37; 118.18 | 0.198 | 3.56 | 0.38; 33.57 | 0.268 | 6.64 | 0.54; 82.32 | 0.141 |
Abbreviations: OR Odds Ratio, CI Confidence interval
acomplete case analyses (missing co-variables for three episodes)
bestimates shown as % change, i.e. (exponentiated coefficients—1)*100
camong episodes with a first recurrence