TABLE 2.

Cytokine mRNA expression in PBMC and in biopsies of the PPD site

Site	Cytokine	Time point	Cytokine mRNA level (% activity)a in:
			IL-2-treated patients (n = 6)	Control patients (n = 4)
PBMC	IFN-γ	Prestudy	100	100
		Midstudy (15 days)	52 ± 11*	107 ± 49
		Poststudy (37 days)	55 ± 23**	90 ± 10
	CD3	Prestudy	100	100
		Midstudy	131 ± 23	120 ± 15
		Poststudy	113 ± 19	95 ± 21
	IFN-γ/CD3 ratio	Prestudy	100	100
		Midstudy	35 ± 7*	89 ± 10
		Poststudy	42 ± 9*	95 ± 12
PPD biopsy (48 h)	IL-2	Prestudy	100	100
		Midstudy (28 days)	175 ± 32**	115 ± 3
	IFN-γ	Prestudy	100	100
		Midstudy	200 ± 106**	110 ± 12
	IL-1β	Prestudy	100	NDb
		Midstudy	76 ± 69	ND
	IL-10	Prestudy	100	ND
		Midstudy	372 ± 176	ND
	IL-12	Prestudy	100	ND
		Midstudy	143 ± 75	ND
	TNF-α	Prestudy	100	ND
		Midstudy	124 ± 45	ND

^aResults are means ± standard errors of the mean. *, P < 0.05; **, P < 0.1. Statistical analyses were carried out for the relative (percent) cytokine levels, comparing midtreatment to pretreatment results and posttreatment to pretreatment results. 

^bND, not done.