TABLE 4.
Effect of rhuIL-2 on antigen-induced gene expression in vitro
| Day | Treatment | IFN-γ (pg/ml) | Area under the curve (fold increase) for cDNA fragmenta:
|
||
|---|---|---|---|---|---|
| B7a | B7b | B17 | |||
| 3 | Control | 0 | 1,057 (1) | 466 (1) | 1,159 (1) |
| M. tuberculosis | 434 | 1,240 (1) | 3,357 (7.2) | 1,822 (1.6) | |
| M. tuberculosis + IL-2 | 2,169 | 1,832 (1.7) | 11,663 (25) | 2,441 (2.1) | |
| 4 | Control | 0 | 713 (1) | 263 (1) | 1,456 (1) |
| M. tuberculosis | 245 | 1,589 (2.2) | 1,503 (5.7) | 5,265 (3.6) | |
| M. tuberculosis + IL-2 | 5,477 | 2,086 (3) | 7,577 (29) | 7,783 (5.3) | |
a
B7a, hnRNP-G; B7b, cytochrome oxidase I; B17, clathrin heavy chain. B7a and B17 were evaluated from total RNA; B7b was evaluated from mRNA. Fold increases are normalized to baseline values. Results are from one representative experiment of three such experiments and are means of triplicate samples.