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. 2024 Jan 27;147(1):25. doi: 10.1007/s00401-023-02672-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Representative images of [¹⁸F]-Flortaucipir (left), [¹⁸F]-MK-6240 (center), and [¹⁸F]-PI-2620 phosphor screen autoradiography experiments of slices containing substantia nigra in a control case (a), retinal pigment epithelium (b) in an dementia lacking distinctive histopathology case, parenchymal hemorrhagic lesions (c) and skin melanocytes (d) of an AD case. Strong binding of Flortaucipir, MK-6240 and PI-2620 was observed in neuromelanin-containing neurons of the substantia nigra (a), melanin containing granules in the retinal pigment epithelium (b), intraparenchymal hemorrhagic lesions (c) and skin melanocytes (d). Scale bars = 1 cm (a–d [¹⁸F]-Flortaucipir, [¹⁸F]-MK-6240 and [¹⁸F]-PI-2620 left panels: phosphor screen autoradiography) and 50 μm (a–d [¹⁸F]-Flortaucipir, [¹⁸F]-MK-6240 and [¹⁸F]-PI-2620 right panels; high resolution nuclear emulsion autoradiography)