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. Author manuscript; available in PMC: 2025 Jan 1.
Published in final edited form as: Schizophr Res. 2023 Jul 28;263:178–190. doi: 10.1016/j.schres.2023.07.015

Table 4.

Adjusted^ polygenic risk scores for European Ancestry set.

OR (95% CI) Standard Error p-value Corrected*

p-value
Depression 1.132 (0.866, 1.482) 0.1374 0.3681 0.5890
Anxiety 1.515 (1.162, 1.975) 0.1354 0.0022 0.0087
Bipolar Disorder 1.718 (1.281, 2.304) 0.1498 0.0003 0.0025
Cross Disorders 1.814 (1.185, 2.777) 0.2172 0.0061 0.0163
Schizophrenia SDs 1.586 (1.122, 2.240) 0.1764 0.0090 0.0179
Alzheimer’s Disease 1.061 (0.826, 1.362) 0.1278 0.6459 0.8612
Autism Spectrum Disorders 0.997 (0.774, 1.284) 0.1289 0.9805 1
Obsessive Compulsive Disorder 1.0003 (0.778, 1.287) 0.1285 0.9980 0.9980
^

polygenic scores were adjusted for age, sex, race, and ancestral principal components, and were further adjusted for a history of that mental illness, for example: depression scores were adjusted for a history of depression as indicated by ICD 9 and 10 codes for depression, anxiety was adjusted for a history of anxiety according to ICD 9 and 10 codes for anxiety, etc. For cross disorders, all ICD 9 and 10 covariates (depression, anxiety, schizophrenia spectrum disorders, Alzheimer’s disease, autism spectrum disorders, obsessive compulsive disorder and a composite covariate representing all other mental health codes not represented by the ones listed above was included.)

*

Corrected using Benjamini-Hochberg Adjusted p-value