Table 4.
Adjusted^ polygenic risk scores for European Ancestry set.
OR (95% CI) | Standard Error | p-value | Corrected* p-value |
|
---|---|---|---|---|
Depression | 1.132 (0.866, 1.482) | 0.1374 | 0.3681 | 0.5890 |
Anxiety | 1.515 (1.162, 1.975) | 0.1354 | 0.0022 | 0.0087 |
Bipolar Disorder | 1.718 (1.281, 2.304) | 0.1498 | 0.0003 | 0.0025 |
Cross Disorders | 1.814 (1.185, 2.777) | 0.2172 | 0.0061 | 0.0163 |
Schizophrenia SDs | 1.586 (1.122, 2.240) | 0.1764 | 0.0090 | 0.0179 |
Alzheimer’s Disease | 1.061 (0.826, 1.362) | 0.1278 | 0.6459 | 0.8612 |
Autism Spectrum Disorders | 0.997 (0.774, 1.284) | 0.1289 | 0.9805 | 1 |
Obsessive Compulsive Disorder | 1.0003 (0.778, 1.287) | 0.1285 | 0.9980 | 0.9980 |
polygenic scores were adjusted for age, sex, race, and ancestral principal components, and were further adjusted for a history of that mental illness, for example: depression scores were adjusted for a history of depression as indicated by ICD 9 and 10 codes for depression, anxiety was adjusted for a history of anxiety according to ICD 9 and 10 codes for anxiety, etc. For cross disorders, all ICD 9 and 10 covariates (depression, anxiety, schizophrenia spectrum disorders, Alzheimer’s disease, autism spectrum disorders, obsessive compulsive disorder and a composite covariate representing all other mental health codes not represented by the ones listed above was included.)
Corrected using Benjamini-Hochberg Adjusted p-value