Table 6.
Adjusted^ polygenic risk scores for African Ancestry set.
OR (95% CI) | Standard Error | p-value | Corrected* p-value |
|
---|---|---|---|---|
Depression | 1.218 (0.748, 1.982) | 0.2486 | 0.428 | 1 |
Anxiety | 1.032 (0.660, 1.614) | 0.2281 | 0.8907 | 1 |
Bipolar Disorder | 1.709 (1.025, 2.850) | 0.2609 | 0.0399 | 0.3192 |
Cross Disorders | 1.390 (0.441, 4.380) | 0.5854 | 0.5735 | 1 |
Schizophrenia SDs | 1.168 (0.582, 2.344) | 0.3556 | 0.6630 | 1 |
Alzheimer’s Disease | 1.469 (0.936, 2.303) | 0.2297 | 0.0943 | 0.3772 |
Autism Spectrum Disorders | 1.054 (0.660, 1.682) | 0.2386 | 0.826 | 1 |
Obsessive Compulsive Disorder | 0.974 (0.633, 1.499) | 0.2200 | 0.905 | 0.9050 |
polygenic scores were adjusted for a history of that mental illness, for example: depression scores were adjusted for a history of depression as indicated by ICD 9 and 10 codes for depression, anxiety was adjusted for a history of anxiety according to ICD 9 and 10 codes for anxiety, etc. For cross disorders, all ICD 9 and 10 covariates (depression, anxiety, schizophrenia spectrum disorders, Alzheimer’s disease, autism spectrum disorders, obsessive compulsive disorder and a composite covariate representing all other mental health codes not represented by the ones listed above was included.)
Corrected using Benjamini-Hochberg Adjusted p-value