Table 3.
Permeability Pe (× 10−6 Cm/s) in the PAMPA-BBB Assay for 10 Commercial Drugs in the Experiment Validation
| Commercial Drugs | Bibliographya | Experimentb |
|---|---|---|
| Testosterone | 17.0 | 18.45 ± 0.13 |
| Estradiol | 12.0 | 13.17 ± 0.34 |
| Progesterone | 9.3 | 9.78 ± 0.19 |
| Chlorpromazine | 6.5 | 7.12 ± 0.22 |
| Caffeine | 1.3 | 2.10 ± 0.23 |
| Corticosterone | 5.1 | 4.90 ± 0.11 |
| Hydrocortisone | 1.9 | 2.10 ± 0.24 |
| Ofloxacin | 0.8 | 0.99 ± 0.08 |
| Atenolol | 0.8 | 0.80 ± 0.07 |
| Theophylline | 0.1 | 0.60 ± 0.23 |
Notes: aTaken from Ref.37 bExperimental data are expressed as mean ± SD from three independent experiments, using PBS: EtOH (70:30) as solvent.