Table 1.
Effects of multiple doses of oral Icz on the pharmacokinetic parameters of CsA in three healthy cats
| Parameters | AUC0–24 (ngh/ml) | Cmax (ng/ml) | tmax (h) | t1/2 (h) | C12 (ng/ml) | C24 (ng/ml) | AUMC0–24 (ngh2/ml) | MRT (h) |
|---|---|---|---|---|---|---|---|---|
| Treatment A | 12531±5506 | 1395±389 | 1.33±0.33 | 12.15±2.19 | 421±227 | 252±163 | 110318±60468 | 8.02±0.92 |
| Treatment B | 22923±3282*, a | 2075±195 | 3.33±0.67 | 15.43±0.83 | 840±170*, b | 522±111* c | 218803±40126* d | 9.45±0.37 |
Values are presented as means±SE. Treatment A=CsA alone. Treatment B=CsA+multiple therapeutic doses of Icz. C12 and C24=CsA blood concentrations at 12 h and 24 h after CsA intake, respectively.
*,a–dStatistically different from treatment group A (P=0.04, 0.02, 0.04 and 0.04, respectively).