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. 2016 Jun 24;6(1):29–42. doi: 10.1016/j.jfms.2003.09.009

Table 3.

Relative effects of TCA parent compounds and intermediate metabolites on NE and 5-HT re-uptake (adapted from Kaplan and Sadock, 1993)

Parent compound Intermediate metabolite NE 5-HT
Desipramine ++ +
Imipramine Desipramine +++ ++
Amitriptyline Nortriptyline ++ ++
Nortriptyline + +
Clomipramine N-desmethyl clomipramine+clomipramine* ++ +++
*

Does not include the specific effect of the intermediate metabolite as a selective serotonin reuptake inhibitor (SSRI)