Table 1.

Effects of a single therapeutic dose of oral clarithromycin (CLM) on the pharmacokinetic parameters of cyclosporine (CsA) in four healthy cats

Parameter	Treatment A (CsA alone)	Treatment B (CsA + CLM)
AUC0–24 (ng•h/ml)	6102 ± 1050	16879 ± 2867 a
Cmax (ng/ml)	553 ± 99	1258 ± 201 b
tmax (h)	2.38 ± 1.25	4.00 ± 0
t1/2 (h)	19.24 ± 4.82	14.31 ± 0.65
C12 (ng/ml)	218 ± 42	710 ± 132 c
C24 (ng/ml)	133 ± 14	400 ± 84 d
AUMC0–24 (ng•h2/ml)	56749 ± 9932	172833 ± 32848 e
MRT0–24 (h)	9.36 ± 0.45	10.16 ± 0.25

In this study, the dosage of CsA and CLM were adjusted to 5 mg/kg and approximately 10 mg/kg (range; 7.96–11.11 mg/kg according to the capsule strength and cat’s weight), respectively. Values are presented as means ± SE

C₁₂ and C₂₄ = CsA blood concentrations at 12 h and 24 h after CsA intake, respectively

^a–eStatistically different from treatment group A (P < 0.02, P < 0.03, P < 0.02, P < 0.04 and P < 0.02, respectively).