Figure 11.

A domestic crossbred cat with invasivecryptococcal rhinitis due to Cryptococcus gattii with extensive secondary invasion of the subcutis of the nasal bridge. Most cats with this infection will respond to long courses (typically 6 to 12 months) of itraconazole (50 to 100 mg once daily) or fluconazole (33 to 50 mg twice daily). Refractory cases require twice weekly amphotericin B subcutaneous infusions (0.5 to 0.7 mg/kg in 350 ml 0.45% NaCl and 2.5% dextrose), ideally in concert with orally administered flucytosine (250 mg every 8 h), to effect a cure.