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. 2024 Jan 10;6(1):141–152. doi: 10.1038/s42255-023-00948-y

Extended Data Fig. 5. Supplementation of αKG rescues the defect in osteoclastogenesis in PHGDH-deficient cells.

Extended Data Fig. 5

a Schematic overview of experimental setup. Osteoclast precursors were treated with cell-permeable αKG either during the first three days (d0 to d3) or during the last three days (d3 to d6) of differentiation. b, c TRAP staining (b) and quantification of TRAP+ MNCs (c) from Phgdhoc+ and Phgdhoc- mice treated with vehicle or αKG (n = 4; one-way ANOVA). Scale bar is 50 µm. Data are means ± s.d.

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