TABLE 2.
Activities of protegrins against C. albicans UC820a
| Protegrin | MICa (μM) | MICb (μM) | Lethal concn (μM) |
|---|---|---|---|
| PG-1 | 2.29 ± 0.13 | 2.83 ± 0.11 | 0.38 ± 0.02 |
| PG-2 | 1.83 ± 0.35 | 2.50 ± 0.34 | 0.38 ± 0.02 |
| PG-3 | 2.21 ± 0.17 | 2.85 ± 0.12 | 0.36 ± 0.01 |
| PG-4 | 4.78 ± 0.74** | 4.90 ± 0.23** | 1.00 ± 0.07** |
| PG-5 | 2.10 ± 0.72 | 2.56 ± 0.18 | 0.35 ± 0.01 |
| d-PG-1 | 1.67 ± 0.21* | 2.35 ± 0.46 | 0.32 ± 0.01 |
a
All radial diffusion assays were performed with underlay gels containing 100 mM NaCl. Results are means ± SEMs from three experiments, except for PG-1 (n = 7). Values were compared to those obtained for PG-1 by unpaired t tests: ∗, P < 0.05, ∗∗, P < 0.01. The other differences were not statistically significant (P > 0.05). The r values (means ± SEMs) of the least-mean-square fits used to calculate the MICa values ranged from 0.995 ± 0.001 to 0.998 ± 0.001.