FIGURE 2.

Infectious disease targets for in situ tomography. (A) Viruses attach to the periphery of cells (i). Interaction with host organelles, such as the endosomes are sometimes required for entry (ii). DNA viruses and some RNA viruses must transport genetic material to the nucleus (iii) before assembly in the cytoplasm (iv). (B) Pathogenic bacteria express motility and virulence machinery which enable them to seek out and infect host cells (i). Upon encountering host cells, bacteria deliver virulence factors which promote host cell entry (ii). Following virulence factor delivery, bacteria enter host cells via endocytosis (iii). (C) Prions can interact and seed membranes at lipid rafts on the host cell surface. (i) Monomeric prion proteins (blue) are attached to lipid rafts by glycosylphosphatidylinositol (GPI) anchors (red). (ii) Prion rods occupy the extracellular space. All these have presented interesting targets for in situ tomography.