FIG. 5.

Effects of a glutamate release inhibitor and glutamate receptor antagonists on the neurotoxicity of epsilon-toxin toward pyramidal cells in the hippocampus. Rats were injected with riluzole (8 mg/kg, i.p.), MK-801 (3 mg/kg, i.p.), CNQX (100 nmol, lateral ventricle), or saline only (n = 8 per group) 30 min before 100 ng of epsilon-toxin per kg was injected i.v. The rats were sacrificed at 4 h p.i. of the toxin. The numbers of dark cells in HE-stained sections of the hippocampus were determined. Values represent means ± SEM. ∗, P <0.01; ∗∗, P < 0.001 (versus the saline group).