Table 1.

Plasma protein binding, acid stability, and plasma half-life for MG-002

	Plasma protein binding (% bound)		SGF stability*	T1/2 (h)
Cmpd	Mouse	Human
MG-002	87 ± 0.5	73.2 ± 1.2	94.5 ± 0.7%	9.97 ± 2.53† 4.11 ± 1.9‡
eFT226	73.4 ± 1.1	79.4 ± 0.3	ND	10.9§

^*Cmpd (50 µM) was incubated in SGF containing pepsin at pH 1.2 for 1 h at 37 °C.

^†Delivered PO 5 mg/kg n = 3 ±SD.

^‡Delivered IV 0.5 mg/kg n = 3 ±SD.

^§Taken from ref. 36—delivered IV 1 mg/kg.