Table 1.

Oxidative stress–inducible genes analyzed in ADPKD mouse models

Gene	Description
Cat	Catalase—breaks down hydrogen peroxide to molecular oxygen and water.
Sod1	Superoxide dismutase 1 (cytosolic)—converts superoxide to water and hydrogen peroxide
Glrx	Glutaredoxin—reduces oxidized glutathione
Gpx	Glutathione peroxidase—reduces peroxides to water using glutathione
Hmox	Heme oxygenase—catalyzes breakdown of heme
Hif1α	Hypoxia-inducible factor 1 alpha—key subunit of a master regulator of the cellular response to hypoxia
Prdx	Peroxiredoxin—thioredoxin-dependent peroxide reductase; reduces peroxides