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. 2024 Jan 18;121(4):e2305745121. doi: 10.1073/pnas.2305745121

Fig. 2.

Fig. 2.

Crystal structure of Osr2HN (PDB ID code 7BWU). (A) The overall structure of Osr2HN. (B) Superposition of OsrHN (yellow) with HN from insect cells (3t1e in green) and a mammalian cell expression system (4fzh in cyan). (C) Disulfide bond of Osr2HN. Disulfide bonds are labeled as red sticks; the cysteine forming the disulfide bonds are C122-C146, C136-C197, C188-C201, C294-C411, C405-C415, and C481-C492. (D) The three types of glycan structure at Asn 431 and 967 of Osr2HN (E) The connection between four HN domains. The black circles mark the N terminus of HN, and the red circles mark the C terminus of HN. The flexible linker between the N terminus and the C terminus is indicated by a dotted line. (F) The epitope map of Osr2HN. Ep1-6 are different epitopes of HN. EP, EP′, EP″, and EP‴ are the same epitopes in different HN domains.