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. 2023 Nov 16;115(1):155–169. doi: 10.1111/cas.16014

FIGURE 7.

FIGURE 7

MicroRNA (miR)‐296‐3p in plasma extracellular vesicles (EVs) is closely associated with tumorigenesis and chemoresistance in patients with ovarian cancer. (A) miR‐296‐3p expression in the blood circulation of patients with ovarian cancer and healthy controls was analyzed using the dbDEMC database. (B) EVs isolated from the plasma of patients with ovarian cancer and healthy controls were observed by transmission electron microscope; white arrowhead signifies EVs (scale bar, 500 nm). (C) Nanoparticle tracking analysis of the isolated EVs. (D) Western blot analysis of EV marker protein expression, including CD9, HSP70, Alix, and Annexin‐V. (E) The miR‐296‐3p expression in plasma EVs of patients with ovarian cancer and healthy controls was detected using real‐time PCR. (F) miR‐296‐3p expression in plasma EVs of drug‐sensitive and drug‐resistant patients with ovarian cancer. *p < 0.05; **p < 0.01. N‐EV, normal control‐derived EVs; T‐EV, tumor patien‐derived EVs.