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(a) Structures of RIPK2 inhibitors, 13 was discovered via DEL screening. (b) Overlaid structures of RIPK2-12 (SB-203580, PDB ID 5AR4) and RIPK2-13 (PDB ID 5AR5) complexes, highlighting the unique bidentate interaction of 13 in the ATP-binding site between the P-loop (S25) and hinge region (M98).76
