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(a) Structures of autotaxin (ATX) inhibitors: 18 was discovered via a DEL screen reported by Cuozzo et al.97 (b) Crystal structure of 18 bound to ATX (blue carbons, PDB entry 6W35),97 overlaid with 17 (GLPG1690, yellow carbons, PDB entry 5MHP)96 and PF-8083 (magenta carbons, PDB entry 5L0K).96
