Table 11. Metabolic Stability of BAY1830839 and BAY1834845 in Hepatocytes.
species/gender |
BAY1830839 |
BAY1834845 |
||
---|---|---|---|---|
CLblood [L/h/kg] | Fmax [%]a | CLblood [L/h/kg] | Fmax [%]a | |
human/male | 0.17 | 87 | stable | 100 |
primate/female | 0.63 | 75 | 0.62 | 75 |
rat/male | 0.47 | 89 | 0.051 | 99 |
dog/female | 0.43 | 80 | stable | 100 |
Fmax: calculated maximal oral availability.