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. 2024 Jan 17;67(2):1225–1242. doi: 10.1021/acs.jmedchem.3c01714

Table 11. Metabolic Stability of BAY1830839 and BAY1834845 in Hepatocytes.

species/gender BAY1830839
BAY1834845
  CLblood [L/h/kg] Fmax [%]a CLblood [L/h/kg] Fmax [%]a
human/male 0.17 87 stable 100
primate/female 0.63 75 0.62 75
rat/male 0.47 89 0.051 99
dog/female 0.43 80 stable 100
a

Fmax: calculated maximal oral availability.