. 2024 Jan 17;67(2):1225–1242. doi: 10.1021/acs.jmedchem.3c01714

Table 3. In Vitro Data for Compound 14 (Containing a N-Methylpiperazine Moiety) and Compound 20 (Containing a Morpholine Ring).

compd	heps(r) CL_blood (L/h/kg), F_max (%)^a	Caco-2 P_app A–B (nm/s), efflux ratio	CYP inhibition IC₅₀ (μM)	CYP induction NOEL (μg/L)
14	2.62, 38	102, 1.0	3A4, 1A2, 2C8, 2C9, 2D6 > 20	1A2 = 7; 3A4 = 1667
20	0.26, 94	190, 0.5	3A4, 1A2, 2C8, 2C9, 2D6 > 10	1A2 = 3333; 3A4 = 3333

In vitro stability in rat hepatocytes (heps(r)). F_max: calculated maximal oral availability.